HOMATROPINE HYDROBROMIDE
DL-Homatropine hydrobromide
CAS: 51-56-9
Molecular Formula: C16H22BrNO3
HOMATROPINE HYDROBROMIDE - Names and Identifiers
HOMATROPINE HYDROBROMIDE - Physico-chemical Properties
| Molecular Formula | C16H22BrNO3 |
| Molar Mass | 356.25 |
| Melting Point | 214-217 °C |
| Boling Point | 403.298°C at 760 mmHg |
| Flash Point | 197.708°C |
| Water Solubility | soluble |
| Solubility | Freely soluble in water, sparingly soluble in alcohol. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 14,4730 |
| Storage Condition | 2-8°C |
| In vitro study | Homatropine (20 μm) alone produced 259 dose ratios in guinea pig atria. The combination of Homatropine (20 μm) with hexamethonium produced only 95.0 dose ratios in guinea pig atria. Homatropine has a similar affinity for muscarinic receptors in the stomach (pA2 = 7.13) and modulates the power (pA2 = 7.21) and ratio (pA2 = 7.07) responses in the atria. sup> [3] |
| In vivo study | Homatropine (20 mg/kg) protected rats from dichlorvos intoxication with a survival rate of 30% and a time to death ranging from 4 to 12 minutes, while Homatropine (10 mg/kg) it has no effect on preventing death. In rats, Homatropine [ |
HOMATROPINE HYDROBROMIDE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | YM5602000 |
| HS Code | 29399900 |
| Hazard Class | 6.1 |
| Packing Group | III |
HOMATROPINE HYDROBROMIDE - Standard
Authoritative Data Verified Data
This product is tropane hydrobromide. Calculated as dry product, the content of C16H21N03 • HBr shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
HOMATROPINE HYDROBROMIDE - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless, easy to deteriorate in light.
- This product is soluble in water, slightly soluble in ethanol, insoluble in ether.
Last Update：2022-01-01 13:42:35
HOMATROPINE HYDROBROMIDE - Differential diagnosis
Authoritative Data Verified Data
- take the test solution under the relevant substance inspection item as the test solution. Another post-hydrobromic acid Matto control was taken, dissolved and diluted with mobile phase to prepare a solution containing about 2mg per 1 ml as a control solution. According to the chromatographic conditions under the items of related substances, 10ul of each of the reference solution and the test solution is injected into the liquid chromatograph respectively, and the chromatogram is recorded, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 11729).
- the product of the aqueous solution of the identification of bromide reaction (General 0301).
Last Update：2022-01-01 13:42:35
HOMATROPINE HYDROBROMIDE - Exam
Authoritative Data Verified Data
acidity
take 0.5g of this product, add 20ml of water to dissolve, add 1 drop of Methyl red indicator solution, if it is red, add 0.02 ml of sodium hydroxide titration solution (0.1 mol/L), and the strain is yellow.
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing about 2mg per 1 ml as a test solution; Take an appropriate amount for precision measurement, A solution containing about 10ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. Take about 5mg of scopolamine hydrobromide in a 50ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake well, take 10ml of scopolamine hydrobromide in a 0.5ml measuring flask, add of test solution, dilute to the scale with the mobile phase and shake well as a system-suitable solution. According to the high performance liquid chromatography (General 0512) test, silica gel was bonded with eighteen alkyl silane as filler; Phosphate buffer [6.8g of potassium dihydrogen phosphate, 6.4g of sodium hexanesulfonate (C6H13S03Na) was added, water was added to dilute to 2.7 ML, and the pH value was adjusted to with phosphoric acid-methanol (67:33) as mobile phase; The column temperature was 40 ° C.; The detection wavelength was 210nm. Take the applicable solution 10 u1 of the system and inject it into the liquid chromatograph. The separation degree of the rear matopin peak and the scopolamine peak shall meet the requirements, and the tailing factor of the rear matopin peak shall not be more than 2.0. Take 10ul of control solution and 10ul of test solution respectively, inject human liquid chromatograph, record chromatogram to 2.5 times of retention time of main component chromatographic peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5% ) , and the sum of each impurity peak area shall not be greater than 2 times the area of the main peak of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 13:42:36
HOMATROPINE HYDROBROMIDE - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add acetic anhydride-glacial acetic acid (7:3)30ml to dissolve, according to the potential titration method (General 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 35.63mg of C16H21N03. HBr.
Last Update：2022-01-01 13:42:37
HOMATROPINE HYDROBROMIDE - Category
Authoritative Data Verified Data
mydriatic drugs.
Last Update：2022-01-01 13:42:37
HOMATROPINE HYDROBROMIDE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:42:37
